Growth Hormone Deficiency

Growth hormone is produced by the anterior pituitary gland. It is responsible for stimulating cell reproduction and the growth of organs, muscles, bones and height. It stimulates the release of insulin-like growth factor 1 (IGF-1) by the liver, which is also important in promoting growth in children and adolescents.

Congenital growth hormone deficiency results from a disruption to the growth hormone axis at the hypothalamus or pituitary gland. It can be due to a known genetic mutation such as the GH1 (growth hormone 1) or GHRHR (growth hormone releasing hormone receptor) genes, or due to another condition such as empty sella syndrome where the pituitary gland is under-developed or damaged.

Acquired growth hormone deficiency can be secondary to infection, trauma or interventions such as surgery.

Growth hormone deficiency can occur in isolation or in combination with other pituitary hormone deficiencies like hypothyroidism, adrenal insufficiency and deficiencies of the gonadotrophins (LH and FSH). When the pituitary does not produce a number of pituitary hormones this is called hypopituitarism or multiple pituitary hormone deficiency.

 

Presentation

Growth hormone deficiency may present at birth or in neonates with:

  • Micropenis (in males)
  • Hypoglycaemia
  • Severe jaundice

Older infants and children can present with:

  • Poor growth, usually stopping or severely slowing from age 2-3
  • Short stature
  • Slow development of movement and strength
  • Delayed puberty 

 

Investigations

Investigation, diagnosis and management will be made by specialists in paediatric endocrinology.

Growth hormone stimulation test:

Growth hormone stimulation tests involve measuring the response to medications that normally stimulate the release of growth hormone. Examples of these medications include glucagon, insulin, arginine and clonidine. Growth hormone levels are monitored regularly for 2-4 hours after administering the medication to assess the hormonal response. In growth hormone deficiency there will be a poor response to stimulation.

Other investigations:

  • Test for other associated hormone deficiencies, for example thyroid and adrenal deficiency
  • MRI brain for structural pituitary or hypothalamus abnormalities
  • Genetic testing for associated genetic conditions such as Turner syndrome and Prader–Willi syndrome
  • Xray (usually of the wrist) or a DEXA scan can determine bone age and help predict final height

 

Treatment

Children with growth hormone deficiency will be managed and followed up by a paediatric endocrinologist.

  • Daily subcutaneous injections of growth hormone (somatropin)
  • Treatment of other associated hormone deficiencies
  • Close monitoring of height and development

 

Last updated August 2019
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